| 2. Round | 01/02/2018 | Deportivo Táchira | - | Santa Fe | 2:3 | ||||
| 2. Round | 09/02/2018 | Santa Fe | - | Deportivo Táchira | 0:0 | ||||
| 3. Round | 14/02/2018 | Santiago Wanderers | - | Santa Fe | 1:2 | ||||
| 3. Round | 21/02/2018 | Santa Fe | - | Santiago Wanderers | 3:0 |  |
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| Group 4 | 01/03/2018 | Santa Fe | - | Emelec | 1:1 | |
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| Group 4 | 05/04/2018 | River Plate | - | Santa Fe | 0:0 | ||||
| Group 4 | 19/04/2018 | Flamengo RJ | - | Santa Fe | 1:1 | ||||
| Group 4 | 26/04/2018 | Santa Fe | - | Flamengo RJ | 0:0 | ||||
| Group 4 | 04/05/2018 | Santa Fe | - | River Plate | 0:1 | ||||
| Group 4 | 24/05/2018 | Emelec | - | Santa Fe | 0:3 |  |
Colombia