| 2. Round | 11/03/2021 | Caracas FC | - | Atlético Junior | 1:2 | ||||
| 2. Round | 18/03/2021 | Atlético Junior | - | Caracas FC | 3:1 |  |
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| 3. Round | 09/04/2021 | Bolívar | - | Atlético Junior | 2:1 | ||||
| 3. Round | 16/04/2021 | Atlético Junior | - | Bolívar | 3:0 | |
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| Group 4 | 23/04/2021 | Atlético Junior | - | Santa Fe | 1:1 | ||||
| Group 4 | 29/04/2021 | River Plate | - | Atlético Junior | 2:1 | ||||
| Group 4 | 07/05/2021 | Atlético Junior | - | Fluminense RJ | 1:1 | ||||
| Group 4 | 13/05/2021 | Atlético Junior | - | River Plate | 1:1 | ||||
| Group 4 | 19/05/2021 | Fluminense RJ | - | Atlético Junior | 1:2 |
Colombia