| 12. Round | 30/07/2021 | Club San José | - | Nacional Potosí | 0:4 | ||||
| 15. Round | 15/08/2021 | Jorge Wilstermann | - | Club San José | 4:0 | ||||
| 22. Round | 20/10/2021 | Bolívar | - | Club San José | 4:1 | ||||
| 25. Round | 01/11/2021 | Independiente Petrolero | - | Club San José | 4:0 | ||||
| 27. Round | 26/11/2021 | Nacional Potosí | - | Club San José | 7:1 | ||||
| 28. Round | 30/11/2021 | Club San José | - | Oriente Petrolero | 0:2 |
Bolivia