| 10. Round | 02/10/2021 | SV 19 Straelen | - | SV Lippstadt 08 | 0:2 | ||||
| 7. Round | 06/10/2021 | VfB Homberg | - | SV 19 Straelen | 0:1 | ||||
| 11. Round | 09/10/2021 | Rot-Weiß Oberhausen | - | SV 19 Straelen | 0:0 |  |
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| 12. Round | 16/10/2021 | SV 19 Straelen | - | KFC Uerdingen 05 | 2:0 | ||||
| 13. Round | 23/10/2021 | SC Wiedenbrück | - | SV 19 Straelen | 2:0 | ||||
| 14. Round | 30/10/2021 | SV 19 Straelen | - | 1. FC Köln II | 1:2 | ||||
| 15. Round | 05/11/2021 | Alemannia Aachen | - | SV 19 Straelen | 5:3 | ||||
| 16. Round | 13/11/2021 | SV 19 Straelen | - | Bor. Mönchengladbach II | 1:0 | |
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| 17. Round | 21/11/2021 | Sportfreunde Lotte | - | SV 19 Straelen | 1:2 | |
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| 18. Round | 27/11/2021 | SV 19 Straelen | - | FC Wegberg-Beeck | 0:0 | ||||
| 19. Round | 04/12/2021 | SV Rödinghausen | - | SV 19 Straelen | 3:0 | ||||
| 20. Round | 11/12/2021 | Rot Weiss Ahlen | - | SV 19 Straelen | 2:0 | ||||
| 21. Round | 18/12/2021 | SV 19 Straelen | - | Rot-Weiss Essen | 0:1 | ||||
| 22. Round | 22/01/2022 | SV 19 Straelen | - | Bonner SC | 0:0 | |
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| 24. Round | 05/02/2022 | SV 19 Straelen | - | Fortuna Köln | 0:2 | |
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| 26. Round | 19/02/2022 | SV 19 Straelen | - | VfB Homberg | 0:4 | ||||
| 27. Round | 26/02/2022 | Preußen Münster | - | SV 19 Straelen | 4:0 |
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