| 2. Round | 19/09/2021 | Montevideo City Torque | - | Plaza Colonia | 2:2 |  |
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| 3. Round | 26/09/2021 | Fénix | - | Montevideo City Torque | 1:1 | |
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| 4. Round | 03/10/2021 | Montevideo City Torque | - | Boston River | 4:3 | ||||
| 5. Round | 09/10/2021 | Montevideo Wanderers | - | Montevideo City Torque | 0:1 | ||||
| 6. Round | 16/10/2021 | Montevideo City Torque | - | Rentistas | 1:2 | ||||
| 7. Round | 21/10/2021 | Peñarol | - | Montevideo City Torque | 3:1 | |
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| 8. Round | 24/10/2021 | Deportivo Maldonado | - | Montevideo City Torque | 2:1 | ||||
| 9. Round | 31/10/2021 | Montevideo City Torque | - | Villa Española | 5:0 | ||||
| 11. Round | 07/11/2021 | Cerrito | - | Montevideo City Torque | 0:2 | ||||
| 12. Round | 13/11/2021 | Liverpool | - | Montevideo City Torque | 1:3 |
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