| 1. Round | 19/08/2017 | Boston River | - | Plaza Colonia | 3:0 | ||||
| 2. Round | 26/08/2017 | River Plate | - | Boston River | 1:1 |  |
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| 3. Round | 03/09/2017 | Boston River | - | Peñarol | 0:1 | |
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| 4. Round | 12/09/2017 | Racing | - | Boston River | 1:1 | ||||
| 5. Round | 18/09/2017 | Boston River | - | El Tanque Sisley | 1:0 | ||||
| 6. Round | 23/09/2017 | Liverpool | - | Boston River | 1:2 | |
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| 8. Round | 05/11/2017 | Boston River | - | Montevideo Wanderers | 1:1 | ||||
| 9. Round | 09/11/2017 | Nacional | - | Boston River | 5:0 | ||||
| 11. Round | 16/11/2017 | Rampla Juniors | - | Boston River | 1:0 | |
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| 12. Round | 19/11/2017 | Boston River | - | Defensor Sporting | 0:1 | |
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| 14. Round | 25/11/2017 | Boston River | - | Juventud de Las Piedras | 3:1 |
Uruguay