| 1. Round | 11/09/2021 | Sud América | - | Montevideo City Torque | 1:2 | ||||
| 2. Round | 19/09/2021 | Montevideo City Torque | - | Plaza Colonia | 2:2 | ||||
| 8. Round | 24/10/2021 | Deportivo Maldonado | - | Montevideo City Torque | 2:1 | ||||
| 12. Round | 13/11/2021 | Liverpool | - | Montevideo City Torque | 1:3 | ||||
| 13. Round | 22/11/2021 | Montevideo City Torque | - | River Plate | 1:1 |  |
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| 14. Round | 29/11/2021 | Cerro Largo | - | Montevideo City Torque | 1:1 | ||||
| 15. Round | 04/12/2021 | Montevideo City Torque | - | Progreso | 1:0 | |
Uruguay