| 1. Round | 08/07/2022 | CF América [Women] | - | Deportivo Toluca [Women] | 2:1 | ||||
| 9. Round | 24/08/2022 | CF América [Women] | - | Cruz Azul [Women] | 3:0 | ||||
| 10. Round | 28/08/2022 | Club Tijuana [Women] | - | CF América [Women] | 1:3 | ||||
| 8. Round | 04/09/2022 | Puebla FC [Women] | - | CF América [Women] | 1:0 | ||||
| 11. Round | 13/09/2022 | CF América [Women] | - | FC Juárez [Women] | 2:0 | ||||
| 12. Round | 20/09/2022 | CF América [Women] | - | CF Monterrey [Women] | 1:2 |  |
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| 13. Round | 22/09/2022 | Atlético San Luis [Women] | - | CF América [Women] | 1:3 | ||||
| 14. Round | 27/09/2022 | CF América [Women] | - | CF Pachuca [Women] | 2:1 | ||||
| 15. Round | 03/10/2022 | Deportivo Guadalajara [Women] | - | CF América [Women] | 2:2 | |
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| 16. Round | 17/10/2022 | CF América [Women] | - | Pumas UNAM [Women] | 6:1 | ||||
| 17. Round | 21/10/2022 | Gallos Blancos [Women] | - | CF América [Women] | 0:1 |
USA
Mexico