| 4. Round | 27/02/2022 | Jorge Wilstermann | - | Independiente Petrolero | 1:0 |  |
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| 6. Round | 13/03/2022 | Universitario de Sucre | - | Independiente Petrolero | 1:2 | |
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| 7. Round | 02/04/2022 | Universitario de Vinto | - | Independiente Petrolero | 2:2 | ||||
| 8. Round | 09/04/2022 | Royal Pari | - | Independiente Petrolero | 5:1 | ||||
| 9. Round | 16/04/2022 | Always Ready | - | Independiente Petrolero | 1:1 | |
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| 10. Round | 19/04/2022 | Independiente Petrolero | - | Real Tomayapo | 1:1 | |
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| 11. Round | 23/04/2022 | Bolívar | - | Independiente Petrolero | 3:1 | ||||
| 13. Round | 08/05/2022 | Independiente Petrolero | - | Universitario de Sucre | 1:0 | |
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| 14. Round | 13/05/2022 | Blooming | - | Independiente Petrolero | 4:0 |
Bolivia