| 4. Round | 12/08/2018 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 3:0 |  |
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| 5. Round | 19/08/2018 | Santos Laguna [U20] | - | UANL Tigres [U20] | 3:3 | ||||
| 7. Round | 27/08/2018 | Santos Laguna [U20] | - | Cruz Azul [U20] | 2:0 | ||||
| 8. Round | 02/09/2018 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 3:2 | ||||
| 3. Round | 08/09/2018 | Santos Laguna [U20] | - | Puebla FC [U20] | 2:3 | ||||
| 9. Round | 14/09/2018 | Santos Laguna [U20] | - | Club León [U20] | 3:4 | ||||
| 10. Round | 23/09/2018 | Santos Laguna [U20] | - | CD Veracruz [U20] | 1:0 | ||||
| 12. Round | 05/10/2018 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 4:3 | ||||
| 13. Round | 20/10/2018 | CF Pachuca [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 14. Round | 26/10/2018 | Santos Laguna [U20] | - | CF Monterrey [U20] | 0:2 | ||||
| 15. Round | 04/11/2018 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 1:2 | ||||
| 16. Round | 11/11/2018 | Santos Laguna [U20] | - | CF América [U20] | 0:0 | ||||
| 17. Round | 25/11/2018 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 4:0 |
Mexico