| 1. Round | 06/01/2019 | Lobos BUAP [U20] | - | Santos Laguna [U20] | 1:2 |  |
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| 2. Round | 13/01/2019 | Santos Laguna [U20] | - | Monarcas Morelia [U20] | 1:0 | ||||
| 3. Round | 18/01/2019 | Puebla FC [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 4. Round | 27/01/2019 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 7:3 | ||||
| 5. Round | 02/02/2019 | UANL Tigres [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 7. Round | 16/02/2019 | Cruz Azul [U20] | - | Santos Laguna [U20] | 2:0 | ||||
| 8. Round | 24/02/2019 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:0 | |
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| 9. Round | 02/03/2019 | Club León [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 10. Round | 08/03/2019 | CD Veracruz [U20] | - | Santos Laguna [U20] | 0:1 | ||||
| 12. Round | 29/03/2019 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 13. Round | 07/04/2019 | Santos Laguna [U20] | - | CF Pachuca [U20] | 1:5 | ||||
| 15. Round | 10/04/2019 | Santos Laguna [U20] | - | Gallos Blancos [U20] | 3:1 | ||||
| 16. Round | 27/04/2019 | CF América [U20] | - | Santos Laguna [U20] | 3:3 | ||||
| 17. Round | 05/05/2019 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 1:1 |
Mexico