| 1. Round | 08/01/2021 | Club Tijuana [U20] | - | Pumas UNAM [U20] | 4:1 | ||||
| 4. Round | 30/01/2021 | Club Tijuana [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 6. Round | 12/02/2021 | Club Tijuana [U20] | - | Club León [U20] | 1:1 | ||||
| 9. Round | 03/03/2021 | Club Tijuana [U20] | - | CF América [U20] | 0:1 | ||||
| 11. Round | 13/03/2021 | Club Tijuana [U20] | - | Santos Laguna [U20] | 3:1 | ||||
| 12. Round | 20/03/2021 | Club Tijuana [U20] | - | Gallos Blancos [U20] | 1:0 | ||||
| 14. Round | 11/04/2021 | Club Tijuana [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 16. Round | 23/04/2021 | Club Tijuana [U20] | - | Club Necaxa [U20] | 3:1 | ||||
| 17. Round | 01/05/2021 | Cruz Azul [U20] | - | Club Tijuana [U20] | 0:1 |
Mexico