| 2. Round | 20/08/2021 | Arsenal FC U23 | - | Crystal Palace U23 | 4:2 | ||||
| 3. Round | 27/08/2021 | Tottenham Hotspur U23 | - | Arsenal FC U23 | 1:2 | ||||
| 9. Round | 22/10/2021 | Arsenal FC U23 | - | Everton FC U23 | 4:0 | ||||
| 10. Round | 29/10/2021 | Leeds United U23 | - | Arsenal FC U23 | 2:4 | ||||
| 11. Round | 06/11/2021 | Arsenal FC U23 | - | Leicester City U23 | 3:3 | ||||
| 16. Round | 07/01/2022 | Brighton & Hove Albion U23 | - | Arsenal FC U23 | 1:1 | ||||
| 17. Round | 14/01/2022 | Arsenal FC U23 | - | West Ham United U23 | 1:1 | ||||
| 18. Round | 21/01/2022 | Derby County U23 | - | Arsenal FC U23 | 1:1 |  |
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| 20. Round | 21/02/2022 | Leicester City U23 | - | Arsenal FC U23 | 1:1 | ||||
| 21. Round | 25/02/2022 | Arsenal FC U23 | - | Liverpool FC U23 | 1:4 | ||||
| 15. Round | 04/03/2022 | Arsenal FC U23 | - | Tottenham Hotspur U23 | 2:1 | ||||
| 22. Round | 14/03/2022 | Arsenal FC U23 | - | Blackburn Rovers U23 | 2:2 | ||||
| 24. Round | 04/04/2022 | Arsenal FC U23 | - | Manchester City U23 | 3:3 | ||||
| 26. Round | 29/04/2022 | Arsenal FC U23 | - | Leeds United U23 | 1:1 |
Netherlands
Nigeria