| 2. Round | 31/07/2021 | Manta | - | Universidad Catolica | 0:1 |  |
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| 3. Round | 07/08/2021 | Deportivo Cuenca | - | Manta | 1:0 | |
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| 4. Round | 15/08/2021 | Manta | - | Mushuc Runa | 0:0 | ||||
| 5. Round | 22/08/2021 | Aucas | - | Manta | 3:0 | ||||
| 6. Round | 28/08/2021 | Manta | - | Orense SC | 0:0 | |
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| 8. Round | 26/09/2021 | Manta | - | LDU Quito | 2:2 | ||||
| 9. Round | 05/10/2021 | Delfín SC | - | Manta | 2:1 |  |
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| 12. Round | 30/10/2021 | Macará | - | Manta | 1:2 |
Ecuador