| 4. Round | 02/10/2021 | SC Freiburg [Women] | - | VfL Wolfsburg [Women] | 2:2 | ||||
| 5. Round | 10/10/2021 | VfL Wolfsburg [Women] | - | 1. FC Köln [Women] | 3:0 | ||||
| 6. Round | 17/10/2021 | 1899 Hoffenheim [Women] | - | VfL Wolfsburg [Women] | 2:1 | ||||
| 7. Round | 05/11/2021 | VfL Wolfsburg [Women] | - | Eintracht Frankfurt [Women] | 3:2 | ||||
| 9. Round | 21/11/2021 | VfL Wolfsburg [Women] | - | SGS Essen [Women] | 5:1 | ||||
| 10. Round | 05/12/2021 | VfL Wolfsburg [Women] | - | FC Carl Zeiss Jena [Women] | 5:0 |  |
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| 11. Round | 11/12/2021 | Bayer Leverkusen [Women] | - | VfL Wolfsburg [Women] | 1:1 | ||||
| 12. Round | 29/01/2022 | Turbine Potsdam [Women] | - | VfL Wolfsburg [Women] | 0:3 | ||||
| 13. Round | 06/02/2022 | VfL Wolfsburg [Women] | - | Werder Bremen [Women] | 3:1 | ||||
| 15. Round | 06/03/2022 | VfL Wolfsburg [Women] | - | SC Freiburg [Women] | 4:1 | ||||
| 16. Round | 11/03/2022 | 1. FC Köln [Women] | - | VfL Wolfsburg [Women] | 1:5 | ||||
| 14. Round | 16/03/2022 | SC Sand [Women] | - | VfL Wolfsburg [Women] | 1:2 | ||||
| 18. Round | 26/03/2022 | Eintracht Frankfurt [Women] | - | VfL Wolfsburg [Women] | 1:4 |
Netherlands