| 4. Round | 28/08/2015 | Willem II | - | NEC Nijmegen | 0:1 | ||||
| 5. Round | 12/09/2015 | Roda JC Kerkrade | - | NEC Nijmegen | 0:0 | ||||
| 8. Round | 03/10/2015 | NEC Nijmegen | - | ADO Den Haag | 4:1 | ||||
| 12. Round | 07/11/2015 | NEC Nijmegen | - | De Graafschap | 2:0 | ||||
| 14. Round | 29/11/2015 | Vitesse | - | NEC Nijmegen | 1:0 | ||||
| 15. Round | 06/12/2015 | NEC Nijmegen | - | PEC Zwolle | 2:2 | ||||
| 16. Round | 12/12/2015 | SC Cambuur | - | NEC Nijmegen | 3:1 | ||||
| 18. Round | 17/01/2016 | NEC Nijmegen | - | Willem II | 1:0 |  |
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| 21. Round | 30/01/2016 | NEC Nijmegen | - | AZ Alkmaar | 0:3 | ||||
| 23. Round | 14/02/2016 | NEC Nijmegen | - | PSV Eindhoven | 0:3 | ||||
| 24. Round | 20/02/2016 | sc Heerenveen | - | NEC Nijmegen | 1:1 |  |
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| 25. Round | 26/02/2016 | SBV Excelsior | - | NEC Nijmegen | 2:0 | ||||
| 26. Round | 06/03/2016 | NEC Nijmegen | - | Heracles Almelo | 1:0 | |
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| 27. Round | 13/03/2016 | AFC Ajax | - | NEC Nijmegen | 2:2 | ||||
| 28. Round | 20/03/2016 | ADO Den Haag | - | NEC Nijmegen | 1:0 | ||||
| 30. Round | 10/04/2016 | FC Utrecht | - | NEC Nijmegen | 3:1 | ||||
| 32. Round | 20/04/2016 | PEC Zwolle | - | NEC Nijmegen | 2:0 | ||||
| 34. Round | 08/05/2016 | Feyenoord | - | NEC Nijmegen | 1:0 |
Netherlands