| 1. Round | 04/01/2002 | Atlas Guadalajara | - | Santos Laguna | 3:3 |  |
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| 3. Round | 19/01/2002 | Reboceros de la Piedad | - | Santos Laguna | 1:0 | ||||
| 4. Round | 26/01/2002 | Santos Laguna | - | Cruz Azul | 2:2 |  |
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| 6. Round | 09/02/2002 | Santos Laguna | - | Club León | 3:0 | ||||
| 10. Round | 02/03/2002 | Santos Laguna | - | Atletico Celaya | 4:1 | ||||
| 11. Round | 09/03/2002 | Deportivo Guadalajara | - | Santos Laguna | 0:0 | ||||
| 12. Round | 16/03/2002 | Santos Laguna | - | UAG Tecos | 3:2 | ||||
| 13. Round | 23/03/2002 | Santos Laguna | - | Puebla FC | 3:0 | ||||
| 14. Round | 29/03/2002 | Atlante | - | Santos Laguna | 2:1 | ||||
| 15. Round | 06/04/2002 | Santos Laguna | - | Monarcas Morelia | 4:3 | ||||
| 17. Round | 13/04/2002 | Santos Laguna | - | CF Pachuca | 3:2 |
Mexico