| 1. Round | 23/08/1980 | FC Wageningen | - | PEC Zwolle | 0:0 | ||||
| 5. Round | 12/09/1980 | FC Twente | - | FC Wageningen | 2:1 | ||||
| 11. Round | 01/11/1980 | FC Wageningen | - | Sparta Rotterdam | 1:2 | ||||
| 14. Round | 29/11/1980 | SBV Excelsior | - | FC Wageningen | 1:2 | ||||
| 16. Round | 13/12/1980 | FC Den Haag | - | FC Wageningen | 3:2 | ||||
| 17. Round | 20/12/1980 | FC Wageningen | - | AZ '67 Alkmaar | 1:2 | ||||
| 20. Round | 13/02/1981 | FC Wageningen | - | AFC Ajax | 0:2 | ||||
| 21. Round | 24/02/1981 | MVV | - | FC Wageningen | 1:0 | ||||
| 22. Round | 06/03/1981 | FC Wageningen | - | FC Twente | 0:1 | ||||
| 15. Round | 20/03/1981 | FC Wageningen | - | FC Groningen | 3:0 |  |
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| 24. Round | 27/03/1981 | FC Wageningen | - | Willem II | 2:1 | ||||
| 25. Round | 04/04/1981 | FC Utrecht | - | FC Wageningen | 5:0 | ||||
| 26. Round | 10/04/1981 | FC Wageningen | - | Go Ahead Eagles | 2:1 | ||||
| 33. Round | 29/05/1981 | FC Wageningen | - | FC Den Haag | 1:2 |
Netherlands