| 1. Round | 10/07/2022 | Gualaceo SC | - | LDU Quito | 0:1 | ||||
| 2. Round | 16/07/2022 | Cumbayá | - | Gualaceo SC | 1:2 |  |
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| 3. Round | 23/07/2022 | Gualaceo SC | - | Deportivo Cuenca | 0:0 | ||||
| 4. Round | 01/08/2022 | Emelec | - | Gualaceo SC | 2:1 | ||||
| 5. Round | 09/08/2022 | Gualaceo SC | - | 9 de Octubre | 1:0 | |
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| 6. Round | 13/08/2022 | Independiente del Valle | - | Gualaceo SC | 2:0 | ||||
| 7. Round | 20/08/2022 | Gualaceo SC | - | Técnico Universitario | 0:3 | ||||
| 8. Round | 28/08/2022 | Mushuc Runa | - | Gualaceo SC | 2:0 | ||||
| 11. Round | 17/09/2022 | Macará | - | Gualaceo SC | 1:1 | |
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| 12. Round | 01/10/2022 | Gualaceo SC | - | Universidad Catolica | 0:1 | ||||
| 13. Round | 09/10/2022 | Guayaquil City | - | Gualaceo SC | 1:0 | ||||
| 14. Round | 16/10/2022 | Gualaceo SC | - | Delfín SC | 2:1 |  |
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Ecuador