| 2. Round | 12/08/2008 | Jorge Wilstermann | - | Real Mamoré | 1:0 |  |
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| 3. Round | 17/08/2008 | Real Mamoré | - | Club Aurora | 2:1 | |
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| 4. Round | 24/08/2008 | CD Guabirá | - | Real Mamoré | 1:3 | ||||
| 6. Round | 17/09/2008 | Real Mamoré | - | Oriente Petrolero | 0:0 | ||||
| 8. Round | 26/09/2008 | Real Mamoré | - | CD Guabirá | 0:1 | ||||
| 10. Round | 03/10/2008 | Blooming | - | Real Mamoré | 2:2 |
Colombia