| 8. Round | 29/09/1979 | FC Twente '65 | - | Sparta Rotterdam | 2:0 | ||||
| 9. Round | 07/10/1979 | SBV Excelsior | - | FC Twente '65 | 2:2 | ||||
| 10. Round | 13/11/1979 | FC Twente '65 | - | AFC Ajax | 1:0 | ||||
| 15. Round | 30/11/1979 | AZ '67 Alkmaar | - | FC Twente '65 | 2:0 | ||||
| 16. Round | 08/12/1979 | FC Twente '65 | - | FC Utrecht | 0:1 | ||||
| 17. Round | 15/12/1979 | Feyenoord | - | FC Twente '65 | 1:1 | ||||
| 19. Round | 19/01/1980 | Willem II | - | FC Twente '65 | 1:0 | ||||
| 21. Round | 02/02/1980 | SC NEC | - | FC Twente '65 | 0:3 |  |
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| 22. Round | 09/02/1980 | FC Twente '65 | - | PSV Eindhoven | 2:1 | ||||
| 20. Round | 19/02/1980 | FC Twente '65 | - | PEC Zwolle | 1:0 | ||||
| 23. Round | 22/02/1980 | MVV | - | FC Twente '65 | 1:0 | ||||
| 24. Round | 01/03/1980 | FC Twente '65 | - | FC Den Haag | 2:0 | ||||
| 25. Round | 08/03/1980 | Sparta Rotterdam | - | FC Twente '65 | 1:0 | ||||
| 26. Round | 15/03/1980 | FC Twente '65 | - | SBV Excelsior | 2:1 | ||||
| 27. Round | 23/03/1980 | AFC Ajax | - | FC Twente '65 | 3:2 | ||||
| 28. Round | 30/03/1980 | FC Twente '65 | - | NAC Breda | 1:4 |
Netherlands