| 8. Round | 14/10/2000 | RBC Roosendaal | - | De Graafschap | 2:4 | ||||
| 10. Round | 01/11/2000 | Feyenoord | - | RBC Roosendaal | 5:1 | ||||
| 11. Round | 04/11/2000 | RBC Roosendaal | - | Fortuna Sittard | 3:1 | ||||
| 11. Round | 09/11/2000 | RBC Roosendaal | - | Willem II | 2:1 |  |
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| 12. Round | 17/11/2000 | Vitesse | - | RBC Roosendaal | 2:1 | ||||
| 3. Round | 28/11/2000 | RBC Roosendaal | - | NAC Breda | 0:1 | ||||
| 17. Round | 16/12/2000 | RBC Roosendaal | - | sc Heerenveen | 0:3 | ||||
| 18. Round | 20/12/2000 | RBC Roosendaal | - | FC Twente | 2:2 | ||||
| 16. Round | 26/01/2001 | PSV Eindhoven | - | RBC Roosendaal | 6:0 | ||||
| 19. Round | 30/01/2001 | NEC Nijmegen | - | RBC Roosendaal | 2:3 | |
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| 19. Round | 02/02/2001 | RBC Roosendaal | - | RKC Waalwijk | 0:3 | |
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| 27. Round | 06/04/2001 | De Graafschap | - | RBC Roosendaal | 2:2 | |
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| 28. Round | 13/04/2001 | RBC Roosendaal | - | Sparta Rotterdam | 1:3 | ||||
| 31. Round | 04/05/2001 | FC Twente | - | RBC Roosendaal | 4:1 |
Suriname