| 3. Round | 29/01/2022 | Inter de Querétaro | - | Escorpiones | 0:2 | ||||
| 4. Round | 05/02/2022 | Escorpiones | - | Montañeses FC | 3:2 |  |
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| 5. Round | 12/02/2022 | Leviatán FC | - | Escorpiones | 1:5 |  |
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| 6. Round | 22/02/2022 | Escorpiones | - | Sporting Canamy | 0:1 | ||||
| 8. Round | 05/03/2022 | Escorpiones | - | Lobos ULMX | 0:1 | |
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| 9. Round | 13/03/2022 | Reboceros de La Piedad | - | Escorpiones | 3:1 | ||||
| 10. Round | 19/03/2022 | Escorpiones | - | Deportivo Dongu | 5:3 | |
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| 11. Round | 26/03/2022 | Cañoneros FC | - | Escorpiones | 0:1 | ||||
| 2. Round | 30/03/2022 | Escorpiones | - | CD Zap | 1:0 | ||||
| 13. Round | 08/04/2022 | Inter Playa | - | Escorpiones | 6:1 | |
Mexico