| 1. Round | 14/08/2017 | Southampton FC U23 | - | Reading FC U23 | 4:0 |  |
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| 2. Round | 21/08/2017 | Wolverhampton Wanderers U23 | - | Southampton FC U23 | 3:0 | ||||
| 3. Round | 25/08/2017 | Southampton FC U23 | - | Blackburn Rovers U23 | 0:1 | ||||
| 4. Round | 11/09/2017 | Aston Villa U23 | - | Southampton FC U23 | 4:0 | ||||
| 5. Round | 18/09/2017 | Southampton FC U23 | - | Stoke City U23 | 3:0 | ||||
| 6. Round | 25/09/2017 | West Bromwich Albion U23 | - | Southampton FC U23 | 0:1 | ||||
| 7. Round | 16/10/2017 | Southampton FC U23 | - | Newcastle United U23 | 6:2 | |
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| 9. Round | 30/10/2017 | Southampton FC U23 | - | Brighton & Hove Albion U23 | 0:1 | ||||
| 10. Round | 20/11/2017 | Southampton FC U23 | - | Fulham FC U23 | 3:4 | ||||
| 11. Round | 26/11/2017 | Middlesbrough FC U23 | - | Southampton FC U23 | 3:3 | |
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| 12. Round | 11/12/2017 | Southampton FC U23 | - | Wolverhampton Wanderers U23 | 2:4 | ||||
| 13. Round | 18/12/2017 | Reading FC U23 | - | Southampton FC U23 | 1:1 |
Ireland
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