| 3. Round | 23/01/2022 | CF América | - | Atlas Guadalajara | 0:2 | ||||
| 4. Round | 06/02/2022 | CF América | - | Atlético San Luis | 2:3 | ||||
| 2. Round | 17/02/2022 | Mazatlán FC | - | CF América | 2:1 | ||||
| 8. Round | 02/03/2022 | CF América | - | Gallos Blancos | 1:1 |  |
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| 10. Round | 13/03/2022 | Deportivo Guadalajara | - | CF América | 0:0 |  |
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| 13. Round | 10/04/2022 | CF América | - | FC Juárez | 3:0 | ||||
| 15. Round | 21/04/2022 | CF América | - | Club León | 2:0 | ||||
| 16. Round | 24/04/2022 | UANL Tigres | - | CF América | 0:2 | ||||
| 17. Round | 01/05/2022 | CF América | - | Cruz Azul | 0:0 |
Mexico
Spain