4. Round | 07/08/2010 | Guaraní | - | Tacuary | 1:0 | ||||
5. Round | 14/08/2010 | Sport Colombia | - | Guaraní | 1:1 | ||||
6. Round | 22/08/2010 | Guaraní | - | Club Nacional | 0:0 | ![]() |
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9. Round | 12/09/2010 | Club Olimpia | - | Guaraní | 2:2 | ||||
10. Round | 17/09/2010 | Cerro Porteño | - | Guaraní | 2:1 | ||||
11. Round | 27/09/2010 | Guaraní | - | Club Rubio Ñu | 1:2 | ||||
12. Round | 03/10/2010 | Guaraní | - | Sol de América | 1:0 | ![]() |
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13. Round | 10/10/2010 | Sportivo Trinidense | - | Guaraní | 1:4 | ![]() ![]() |
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16. Round | 24/10/2010 | Guaraní | - | Sport Colombia | 3:0 | ![]() ![]() |
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17. Round | 30/10/2010 | Club Nacional | - | Guaraní | 0:1 | ||||
18. Round | 05/11/2010 | Guaraní | - | Libertad | 2:0 | ![]() |
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19. Round | 13/11/2010 | 3 de Febrero | - | Guaraní | 4:0 | ||||
20. Round | 21/11/2010 | Guaraní | - | Club Olimpia | 0:0 | ![]() |
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21. Round | 28/11/2010 | Guaraní | - | Cerro Porteño | 1:2 |