| 16. Round | 29/01/2022 | AO Egaleo | - | Asteras Vlachioti | 1:0 | ||||
| 11. Round | 02/02/2022 | Asteras Vlachioti | - | Diagoras FC | 2:0 |  |
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| 17. Round | 06/02/2022 | Asteras Vlachioti | - | Irodotos | 1:3 | |
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| 12. Round | 09/02/2022 | PAE Chania | - | Asteras Vlachioti | 3:1 | ||||
| 21. Round | 27/02/2022 | AE Kifisias | - | Asteras Vlachioti | 2:1 | ||||
| 22. Round | 05/03/2022 | Asteras Vlachioti | - | AEK Athen II | 1:1 | |
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| 23. Round | 09/03/2022 | PS Kalamata | - | Asteras Vlachioti | 1:0 | ||||
| 24. Round | 12/03/2022 | Asteras Vlachioti | - | Panathinaikos II | 3:1 | ||||
| 29. Round | 06/04/2022 | Asteras Vlachioti | - | PAE Chania | 0:0 | ||||
| 30. Round | 10/04/2022 | APS Zakynthos | - | Asteras Vlachioti | 1:1 | ||||
| 31. Round | 13/04/2022 | Asteras Vlachioti | - | OFI Ierapetra | 4:1 | ||||
| 32. Round | 17/04/2022 | GS Kallithea | - | Asteras Vlachioti | 5:1 | ||||
| 34. Round | 01/05/2022 | Irodotos | - | Asteras Vlachioti | 2:1 |
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