| 2. Round | 31/07/2022 | Achuapa | - | CSD Municipal | 1:0 | ||||
| 3. Round | 07/08/2022 | CSD Municipal | - | Iztapa | 1:0 | ||||
| 5. Round | 13/08/2022 | CSD Municipal | - | Deportivo Malacateco | 4:1 | ||||
| 6. Round | 21/08/2022 | Comunicaciones | - | CSD Municipal | 2:2 | ||||
| 7. Round | 28/08/2022 | CSD Municipal | - | Deportivo Guastatoya | 0:0 | ||||
| 9. Round | 03/09/2022 | CSD Municipal | - | Xelaju MC | 1:1 | ||||
| 11. Round | 17/09/2022 | CSD Municipal | - | Deportivo Xinabajul | 2:0 |  |
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| 13. Round | 01/10/2022 | CSD Municipal | - | Achuapa | 1:1 | |
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| 15. Round | 16/10/2022 | CSD Municipal | - | Antigua GFC | 0:1 | ||||
| 17. Round | 29/10/2022 | CSD Municipal | - | Comunicaciones | 2:3 |  |
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| 12. Round | 02/11/2022 | Cobán Imperial | - | CSD Municipal | 0:0 | |
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| 18. Round | 06/11/2022 | Deportivo Guastatoya | - | CSD Municipal | 1:3 | ||||
| 19. Round | 12/11/2022 | CSD Municipal | - | Deportivo Mixco | 1:0 | |
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| 20. Round | 17/11/2022 | Xelaju MC | - | CSD Municipal | 1:1 | ||||
| 21. Round | 23/11/2022 | CSD Municipal | - | Santa Lucía | 2:0 | |
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| 22. Round | 27/11/2022 | Deportivo Xinabajul | - | CSD Municipal | 0:1 |
Guatemala
USA