| 2. Round | 11/01/2014 | Cruz Azul | - | Santos Laguna | 2:1 | ||||
| 3. Round | 18/01/2014 | Santos Laguna | - | Puebla FC | 0:0 | ||||
| 4. Round | 25/01/2014 | Gallos Blancos | - | Santos Laguna | 0:0 |  |
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| 5. Round | 01/02/2014 | Santos Laguna | - | Deportivo Toluca | 2:0 | ||||
| 6. Round | 09/02/2014 | UANL Tigres | - | Santos Laguna | 1:1 | ||||
| 7. Round | 15/02/2014 | Santos Laguna | - | Club Tijuana | 3:2 | ||||
| 8. Round | 23/02/2014 | Club León | - | Santos Laguna | 4:2 |  |
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| 10. Round | 08/03/2014 | CF América | - | Santos Laguna | 2:4 | |
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| 11. Round | 16/03/2014 | Santos Laguna | - | CF Pachuca | 3:1 | |
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| 12. Round | 22/03/2014 | Monarcas Morelia | - | Santos Laguna | 2:2 | |
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| 13. Round | 29/03/2014 | Santos Laguna | - | Pumas UNAM | 2:1 | |
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| 14. Round | 06/04/2014 | CF Monterrey | - | Santos Laguna | 2:2 | |
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| 16. Round | 20/04/2014 | Santos Laguna | - | Chiapas FC | 2:3 | ||||
| 17. Round | 26/04/2014 | CD Veracruz | - | Santos Laguna | 2:2 |
Uruguay