| 4. Round | 05/08/2021 | Alianza Lima | - | Academia Cantolao | 2:1 | ||||
| 5. Round | 08/08/2021 | Universidad San Martín | - | Alianza Lima | 0:2 | ||||
| 6. Round | 14/08/2021 | Alianza Lima | - | Deportivo Municipal | 1:0 | ||||
| 7. Round | 19/08/2021 | Universitario de Deportes | - | Alianza Lima | 1:2 | ||||
| 8. Round | 23/08/2021 | Alianza Lima | - | Sport Huancayo | 1:1 | ||||
| 11. Round | 17/09/2021 | Cusco FC | - | Alianza Lima | 0:2 | ||||
| 14. Round | 02/10/2021 | Alianza Lima | - | Universidad Técnica | 2:0 | ||||
| 17. Round | 29/10/2021 | Cienciano | - | Alianza Lima | 1:1 |
Uruguay