| 4. Round | 29/08/2020 | 9 de Octubre | - | Atlético Santo Domingo | 1:1 | ||||
| 5. Round | 05/09/2020 | Atlético Santo Domingo | - | Independiente Juniors | 0:1 |  |
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| 6. Round | 11/09/2020 | Atlético Santo Domingo | - | América de Quito | 1:0 | ||||
| 7. Round | 16/09/2020 | Chacaritas FC | - | Atlético Santo Domingo | 3:3 | ||||
| 8. Round | 20/09/2020 | Atlético Santo Domingo | - | Atlético Porteño | 0:0 | ||||
| 9. Round | 26/09/2020 | Fuerza Amarilla | - | Atlético Santo Domingo | 0:0 | |
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| 10. Round | 03/10/2020 | Atlético Santo Domingo | - | Gualaceo SC | 0:1 | ||||
| 11. Round | 11/10/2020 | Manta | - | Atlético Santo Domingo | 1:0 | ||||
| 12. Round | 17/10/2020 | Atlético Santo Domingo | - | 9 de Octubre | 1:4 | ||||
| 13. Round | 23/10/2020 | Independiente Juniors | - | Atlético Santo Domingo | 0:0 | ||||
| 16. Round | 05/11/2020 | Atlético Porteño | - | Atlético Santo Domingo | 0:1 | ||||
| 17. Round | 08/11/2020 | Atlético Santo Domingo | - | Fuerza Amarilla | 0:0 | ||||
| 18. Round | 14/11/2020 | Santa Rita | - | Atlético Santo Domingo | 0:0 |
Ecuador