| 23. Round | 29/01/2022 | KFC Uerdingen 05 | - | 1. FC Köln II | 2:2 | ||||
| 24. Round | 05/02/2022 | Alemannia Aachen | - | KFC Uerdingen 05 | 3:2 | ||||
| 25. Round | 12/02/2022 | KFC Uerdingen 05 | - | Bor. Mönchengladbach II | 1:4 | ||||
| 27. Round | 26/02/2022 | KFC Uerdingen 05 | - | FC Wegberg-Beeck | 2:0 | ||||
| 28. Round | 05/03/2022 | SV Rödinghausen | - | KFC Uerdingen 05 | 0:1 | ||||
| 29. Round | 12/03/2022 | KFC Uerdingen 05 | - | Rot Weiss Ahlen | 1:1 | ||||
| 30. Round | 19/03/2022 | Rot-Weiss Essen | - | KFC Uerdingen 05 | 3:0 | ||||
| 31. Round | 26/03/2022 | KFC Uerdingen 05 | - | SV 19 Straelen | 4:1 | ||||
| 26. Round | 06/04/2022 | Sportfreunde Lotte | - | KFC Uerdingen 05 | 0:1 | ||||
| 33. Round | 09/04/2022 | KFC Uerdingen 05 | - | Fortuna Köln | 1:1 | ||||
| 35. Round | 23/04/2022 | KFC Uerdingen 05 | - | VfB Homberg | 0:4 | ||||
| 36. Round | 29/04/2022 | Preußen Münster | - | KFC Uerdingen 05 | 3:0 | ||||
| 37. Round | 07/05/2022 | KFC Uerdingen 05 | - | FC Schalke 04 II | 3:4 | ||||
| 38. Round | 14/05/2022 | SV Lippstadt 08 | - | KFC Uerdingen 05 | 3:4 |
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