| 1. Round | 04/07/2023 | Club León | - | Deportivo Guadalajara | 1:2 |  |
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| 2. Round | 09/07/2023 | Deportivo Guadalajara | - | Atlético San Luis | 3:1 | |
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| 3. Round | 14/07/2023 | Deportivo Guadalajara | - | Club Necaxa | 2:0 | ||||
| 4. Round | 19/08/2023 | FC Juárez | - | Deportivo Guadalajara | 1:1 | ||||
| 5. Round | 23/08/2023 | Deportivo Guadalajara | - | Club Tijuana | 1:0 | ||||
| 6. Round | 27/08/2023 | Santos Laguna | - | Deportivo Guadalajara | 2:1 | ||||
| 7. Round | 04/09/2023 | Deportivo Guadalajara | - | CF Monterrey | 1:2 | ||||
| 8. Round | 17/09/2023 | CF América | - | Deportivo Guadalajara | 4:0 | ||||
| 9. Round | 24/09/2023 | Deportivo Guadalajara | - | CF Pachuca | 0:0 | ||||
| 11. Round | 27/09/2023 | Deportivo Guadalajara | - | Mazatlán FC | 1:3 | ||||
| 12. Round | 08/10/2023 | Deportivo Guadalajara | - | Atlas Guadalajara | 4:1 | ||||
| 13. Round | 21/10/2023 | Puebla FC | - | Deportivo Guadalajara | 0:2 | ||||
| 14. Round | 29/10/2023 | Deportivo Guadalajara | - | UANL Tigres | 0:4 | ||||
| 15. Round | 01/11/2023 | Gallos Blancos | - | Deportivo Guadalajara | 1:2 | ||||
| 16. Round | 05/11/2023 | Deportivo Guadalajara | - | Cruz Azul | 1:0 | |
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| 17. Round | 12/11/2023 | Pumas UNAM | - | Deportivo Guadalajara | 1:0 |  |
Mexico