| 2. Round | 10/07/2022 | Club León [U20] | - | Pumas UNAM [U20] | 3:2 |  |
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| 3. Round | 15/07/2022 | Puebla FC [U20] | - | Club León [U20] | 3:1 | ||||
| 5. Round | 26/07/2022 | Club León [U20] | - | Deportivo Toluca [U20] | 0:0 | ||||
| 16. Round | 15/09/2022 | Cruz Azul [U20] | - | Club León [U20] | 1:1 | ||||
| 17. Round | 02/10/2022 | Club León [U20] | - | Club Tijuana [U20] | 1:0 |
Mexico