| 1. Round | 12/08/2020 | Villa Española | - | Albion | 3:2 |  |
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| 2. Round | 17/08/2020 | Rocha | - | Villa Española | 1:0 | ||||
| 3. Round | 24/08/2020 | Sud América | - | Villa Española | 0:4 | ||||
| 4. Round | 01/09/2020 | Villa Española | - | Atenas | 2:2 | |
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| 5. Round | 04/09/2020 | Central Español | - | Villa Española | 2:3 | ||||
| 6. Round | 07/09/2020 | Villa Española | - | Rampla Juniors | 1:2 | ||||
| 9. Round | 21/09/2020 | Racing | - | Villa Española | 2:3 | |
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| 10. Round | 29/09/2020 | Villa Española | - | Cerrito | 1:2 | |
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| 16. Round | 30/10/2020 | Villa Española | - | Central Español | 1:1 | ||||
| 17. Round | 03/11/2020 | Rampla Juniors | - | Villa Española | 0:0 | ||||
| 18. Round | 10/11/2020 | Villa Española | - | Villa Teresa | 3:0 | ||||
| 19. Round | 17/11/2020 | Juventud de Las Piedras | - | Villa Española | 0:0 | |
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| 21. Round | 24/11/2020 | Cerrito | - | Villa Española | 1:1 |  |
Uruguay