| Quarter-finals | 13/05/2021 | Deportivo Toluca | - | Cruz Azul | 2:1 | ||||
| Quarter-finals | 16/05/2021 | Cruz Azul | - | Deportivo Toluca | 3:1 |  |
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| Semi-finals | 20/05/2021 | CF Pachuca | - | Cruz Azul | 0:0 |  |
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| Semi-finals | 23/05/2021 | Cruz Azul | - | CF Pachuca | 1:0 | ||||
| Final | 28/05/2021 | Santos Laguna | - | Cruz Azul | 0:1 | ||||
| Final | 31/05/2021 | Cruz Azul | - | Santos Laguna | 1:1 | |
Uruguay