| 1. Round | 28/08/2008 | Aragua FC | - | Deportivo Guadalajara | 1:2 | ||||
| 1. Round | 18/09/2008 | Deportivo Guadalajara | - | Aragua FC | 1:1 |  |
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| Round of 16 | 25/09/2008 | Deportivo Guadalajara | - | Athletico Paranaense | 2:2 | ||||
| Round of 16 | 01/10/2008 | Athletico Paranaense | - | Deportivo Guadalajara | 3:4 | ||||
| Quarter-finals | 22/10/2008 | River Plate | - | Deportivo Guadalajara | 1:2 |
Mexico