| 1. Round | 21/07/2012 | Gallos Blancos (old) | - | Club León | 0:2 | ||||
| 2. Round | 28/07/2012 | Club León | - | Club Tijuana | 4:0 | ||||
| 3. Round | 05/08/2012 | Deportivo Toluca | - | Club León | 2:1 | ||||
| 4. Round | 11/08/2012 | Club León | - | Santos Laguna | 3:0 | ||||
| 5. Round | 18/08/2012 | Cruz Azul | - | Club León | 1:1 | ||||
| 6. Round | 25/08/2012 | Club León | - | Monarcas Morelia | 1:3 |  |
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| 7. Round | 02/09/2012 | Club San Luis | - | Club León | 0:2 | ||||
| 8. Round | 15/09/2012 | Club León | - | Deportivo Guadalajara | 1:2 |  |
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| 10. Round | 29/09/2012 | Club León | - | CF Monterrey | 2:0 | ||||
| 11. Round | 04/10/2012 | Club León | - | Pumas UNAM | 2:1 | ||||
| 12. Round | 07/10/2012 | CF Pachuca | - | Club León | 1:1 | ||||
| 13. Round | 14/10/2012 | Club León | - | UANL Tigres | 2:0 | ||||
| 14. Round | 20/10/2012 | CF América | - | Club León | 2:1 | ||||
| 15. Round | 27/10/2012 | Club León | - | Jaguares Chiapas | 4:1 | ||||
| 16. Round | 05/11/2012 | Atlante | - | Club León | 2:3 | ||||
| 17. Round | 10/11/2012 | Club León | - | Atlas Guadalajara | 3:1 |
Mexico