| 5. Round | 08/10/2022 | ADO Den Haag [U21] | - | De Graafschap [U21] | 1:0 | ||||
| 6. Round | 15/10/2022 | De Graafschap [U21] | - | FC Groningen [U21] | 0:4 | ||||
| 7. Round | 22/10/2022 | Feyenoord [U21] | - | De Graafschap [U21] | 3:2 | ||||
| 8. Round | 29/10/2022 | Almere City FC [U21] | - | De Graafschap [U21] | 2:1 |  |
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| 9. Round | 05/11/2022 | De Graafschap [U21] | - | Willem II [U21] | 1:0 | |
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| 10. Round | 12/11/2022 | FC Emmen [U21] | - | De Graafschap [U21] | 1:2 | ||||
| 11. Round | 19/11/2022 | De Graafschap [U21] | - | PEC Zwolle [U21] | 2:1 | ||||
| 12. Round | 26/11/2022 | De Graafschap [U21] | - | ADO Den Haag [U21] | 0:0 | ||||
| 14. Round | 17/12/2022 | FC Groningen [U21] | - | De Graafschap [U21] | 1:1 |
Netherlands