1. Round | 13/03/2022 | San Antonio FC | - | Detroit City FC | 1:0 | ||||
1. Round | 28/03/2022 | Rio Grande Valley FC | - | San Antonio FC | 1:2 | ||||
2. Round | 03/04/2022 | San Antonio FC | - | Phoenix Rising | 0:2 | ||||
2. Round | 10/04/2022 | Orange County SC | - | San Antonio FC | 0:1 | ||||
3. Round | 01/05/2022 | San Antonio FC | - | Monterey Bay FC | 6:0 | ||||
3. Round | 15/05/2022 | Miami FC | - | San Antonio FC | 0:2 | ||||
4. Round | 29/06/2022 | San Antonio FC | - | FC Tulsa | 2:1 | ||||
8. Round | 09/10/2022 | Birmingham Legion | - | San Antonio FC | 1:2 |