| 1. Round | 15/01/2022 | Cimarrones de Sonora II | - | Alacranes de Durango | 1:1 | ||||
| 2. Round | 22/01/2022 | Alacranes de Durango | - | Saltillo FC | 3:1 | ||||
| 5. Round | 12/02/2022 | Gavilanes de Matamoros | - | Alacranes de Durango | 1:1 | ||||
| 7. Round | 26/02/2022 | Tecos Fútbol Club | - | Alacranes de Durango | 0:2 | ||||
| 12. Round | 02/04/2022 | Alacranes de Durango | - | Tuzos de la UAZ | 1:1 |
Mexico