| Round of 16 | 23/02/2018 | Santa Tecla FC | - | Seattle Sounders | 2:1 | ||||
| Round of 16 | 02/03/2018 | Seattle Sounders | - | Santa Tecla FC | 4:0 | ||||
| Quarter-finals | 08/03/2018 | Seattle Sounders | - | Deportivo Guadalajara | 1:0 |  |
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| Quarter-finals | 15/03/2018 | Deportivo Guadalajara | - | Seattle Sounders | 3:0 | |
USA