| 1. Round | 18/07/2021 | Club Olimpia | - | River Plate | 1:3 |  |
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| 4. Round | 07/08/2021 | Guaraní | - | Club Olimpia | 3:1 | ||||
| 5. Round | 14/08/2021 | Club Olimpia | - | Cerro Porteño | 0:3 | ||||
| 6. Round | 23/08/2021 | Sportivo Luqueño | - | Club Olimpia | 2:0 | ||||
| 8. Round | 13/09/2021 | Libertad | - | Club Olimpia | 0:3 | |
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| 10. Round | 26/09/2021 | River Plate | - | Club Olimpia | 1:2 | ||||
| 11. Round | 02/10/2021 | Club Olimpia | - | 12 de Octubre de Itauguá | 1:2 |
Paraguay