| 1. Round | 12/09/2021 | Bayer Leverkusen [Youth B] | - | Bor. Mönchengladbach [Youth B] | 0:4 | ||||
| 2. Round | 18/09/2021 | Borussia Dortmund [Youth B] | - | Bayer Leverkusen [Youth B] | 3:0 | ||||
| 3. Round | 26/09/2021 | Bayer Leverkusen [Youth B] | - | Fortuna Düsseldorf [Youth B] | 0:2 | ||||
| 4. Round | 02/10/2021 | Arminia Bielefeld [Youth B] | - | Bayer Leverkusen [Youth B] | 0:0 | ||||
| 6. Round | 30/10/2021 | Bayer Leverkusen [Youth B] | - | SV Lippstadt 08 [Youth B] | 2:0 | ||||
| 7. Round | 06/11/2021 | VfL Bochum [Youth B] | - | Bayer Leverkusen [Youth B] | 2:0 | ||||
| 8. Round | 27/11/2021 | Bayer Leverkusen [Youth B] | - | Preußen Münster [Youth B] | 2:3 | ||||
| 10. Round | 12/12/2021 | Bayer Leverkusen [Youth B] | - | Fortuna Köln [Youth B] | 2:0 | ||||
| 15. Round | 02/04/2022 | 1. FC Köln [Youth B] | - | Bayer Leverkusen [Youth B] | 0:1 |  |
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| 16. Round | 09/04/2022 | Bayer Leverkusen [Youth B] | - | Wuppertaler SV [Youth B] | 4:1 | ||||
| 17. Round | 23/04/2022 | Bayer Leverkusen [Youth B] | - | SG Unterrath 12/24 [Youth B] | 6:1 |  |
Netherlands
Nigeria