| 2. Round | 14/08/2022 | FC Volendam | - | NEC Nijmegen | 1:4 |  |
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| 4. Round | 26/08/2022 | NEC Nijmegen | - | FC Groningen | 1:1 | ||||
| 3. Round | 01/09/2022 | AZ Alkmaar | - | NEC Nijmegen | 1:1 |  |
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| 5. Round | 04/09/2022 | sc Heerenveen | - | NEC Nijmegen | 0:0 | ||||
| 12. Round | 30/10/2022 | PSV Eindhoven | - | NEC Nijmegen | 3:0 | ||||
| 13. Round | 04/11/2022 | SC Cambuur | - | NEC Nijmegen | 0:1 | ||||
| 14. Round | 13/11/2022 | NEC Nijmegen | - | RKC Waalwijk | 6:1 | ||||
| 21. Round | 11/02/2023 | NEC Nijmegen | - | SC Cambuur | 0:0 | ||||
| 22. Round | 19/02/2023 | SBV Excelsior | - | NEC Nijmegen | 0:3 | ||||
| 23. Round | 25/02/2023 | NEC Nijmegen | - | FC Volendam | 3:0 | ||||
| 25. Round | 12/03/2023 | NEC Nijmegen | - | FC Utrecht | 2:2 | ||||
| 26. Round | 18/03/2023 | RKC Waalwijk | - | NEC Nijmegen | 1:3 | ||||
| 27. Round | 01/04/2023 | NEC Nijmegen | - | PSV Eindhoven | 2:4 | ||||
| 28. Round | 09/04/2023 | FC Emmen | - | NEC Nijmegen | 0:0 | ||||
| 29. Round | 16/04/2023 | NEC Nijmegen | - | Vitesse | 1:4 | ||||
| 30. Round | 25/04/2023 | FC Groningen | - | NEC Nijmegen | 0:1 | |
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| 31. Round | 06/05/2023 | NEC Nijmegen | - | sc Heerenveen | 2:3 | ||||
| 32. Round | 12/05/2023 | FC Twente | - | NEC Nijmegen | 4:0 | ||||
| 33. Round | 21/05/2023 | NEC Nijmegen | - | AZ Alkmaar | 0:3 |
Netherlands