| 2. Round | 19/08/2016 | Manchester United | - | Southampton FC | 2:0 | ||||
| 4. Round | 10/09/2016 | Arsenal FC | - | Southampton FC | 2:1 | ||||
| 5. Round | 18/09/2016 | Southampton FC | - | Swansea City | 1:0 | ||||
| 8. Round | 16/10/2016 | Southampton FC | - | Burnley FC | 3:1 | ||||
| 9. Round | 23/10/2016 | Manchester City | - | Southampton FC | 1:1 |  |
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| 10. Round | 30/10/2016 | Southampton FC | - | Chelsea FC | 0:2 | ||||
| 11. Round | 06/11/2016 | Hull City | - | Southampton FC | 2:1 | |
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| 13. Round | 27/11/2016 | Southampton FC | - | Everton FC | 1:0 | ||||
| 15. Round | 11/12/2016 | Southampton FC | - | Middlesbrough FC | 1:0 | ||||
| 17. Round | 18/12/2016 | AFC Bournemouth | - | Southampton FC | 1:3 | |
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| 20. Round | 02/01/2017 | Everton FC | - | Southampton FC | 3:0 | ||||
| 22. Round | 22/01/2017 | Southampton FC | - | Leicester City | 3:0 | ||||
| 23. Round | 31/01/2017 | Swansea City | - | Southampton FC | 2:1 | ||||
| 27. Round | 04/03/2017 | Watford FC | - | Southampton FC | 3:4 | ||||
| 32. Round | 08/04/2017 | West Bromwich Albion | - | Southampton FC | 0:1 |  |
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| 37. Round | 13/05/2017 | Middlesbrough FC | - | Southampton FC | 1:2 |
Netherlands
