| 1. Round | 10/08/2015 | Jong PSV | - | Go Ahead Eagles | 1:0 | ||||
| 2. Round | 14/08/2015 | MVV | - | Jong PSV | 2:3 | ||||
| 5. Round | 29/08/2015 | RKC Waalwijk | - | Jong PSV | 1:2 | ||||
| 6. Round | 11/09/2015 | FC Volendam | - | Jong PSV | 3:0 | ||||
| 10. Round | 16/10/2015 | Fortuna Sittard | - | Jong PSV | 1:1 |  |
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| 14. Round | 23/11/2015 | Jong PSV | - | Jong Ajax | 3:3 | ||||
| 15. Round | 27/11/2015 | Jong PSV | - | FC Dordrecht | 1:4 | ||||
| 16. Round | 30/11/2015 | FC Den Bosch | - | Jong PSV | 0:0 |  |
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| 21. Round | 18/01/2016 | Jong PSV | - | MVV | 2:0 | |
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| 23. Round | 01/02/2016 | Jong PSV | - | RKC Waalwijk | 3:1 | ||||
| 25. Round | 12/02/2016 | Jong PSV | - | FC Volendam | 2:2 | ||||
| 26. Round | 15/02/2016 | Sparta Rotterdam | - | Jong PSV | 1:0 | ||||
| 27. Round | 19/02/2016 | Jong PSV | - | FC Emmen | 0:0 | ||||
| 28. Round | 26/02/2016 | Achilles'29 | - | Jong PSV | 3:2 | |
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| 29. Round | 07/03/2016 | Jong PSV | - | Fortuna Sittard | 0:1 | ||||
| 30. Round | 11/03/2016 | Telstar | - | Jong PSV | 1:1 | ||||
| 32. Round | 18/03/2016 | Jong Ajax | - | Jong PSV | 1:2 | |
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| 33. Round | 04/04/2016 | Jong PSV | - | FC Oss | 3:1 | ||||
| 35. Round | 11/04/2016 | Jong PSV | - | FC Den Bosch | 2:1 | ||||
| 37. Round | 22/04/2016 | Jong PSV | - | FC Eindhoven | 2:0 | ||||
| 38. Round | 29/04/2016 | Almere City FC | - | Jong PSV | 7:0 |  |
Belgium