| 2. Round | 14/01/2018 | Club León | - | Deportivo Toluca | 3:1 | ||||
| 6. Round | 11/02/2018 | Club León | - | Puebla FC | 2:1 | ||||
| 7. Round | 15/02/2018 | Santos Laguna | - | Club León | 5:1 | ||||
| 10. Round | 04/03/2018 | Club León | - | Pumas UNAM | 3:0 | ||||
| 11. Round | 11/03/2018 | CF América | - | Club León | 2:0 | ||||
| 12. Round | 18/03/2018 | Club León | - | Lobos BUAP | 2:2 | ||||
| 13. Round | 01/04/2018 | UANL Tigres | - | Club León | 4:1 | ||||
| 14. Round | 08/04/2018 | Club León | - | Monarcas Morelia | 2:3 | ||||
| 15. Round | 16/04/2018 | CD Veracruz | - | Club León | 1:2 |  |
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| 16. Round | 22/04/2018 | Club León | - | Club Tijuana | 1:1 | ||||
| 17. Round | 29/04/2018 | Deportivo Guadalajara | - | Club León | 0:2 |
Mexico