| 1. Round | 25/06/2022 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 1:0 | ||||
| 2. Round | 02/07/2022 | Club Tijuana [U16] | - | Santos Laguna [U16] | 1:2 | ||||
| 3. Round | 09/07/2022 | Santos Laguna [U16] | - | CF Monterrey [U16] | 3:1 | ||||
| 4. Round | 16/07/2022 | Atlético San Luis [U16] | - | Santos Laguna [U16] | 3:2 |
Mexico