| 1. Round | 11/09/2021 | Panetolikos | - | Asteras Tripolis | 0:0 | ||||
| 2. Round | 19/09/2021 | Atromitos | - | Panetolikos | 1:2 | ||||
| 3. Round | 22/09/2021 | Panetolikos | - | PAOK Saloniki | 1:2 |  |
|||
| 4. Round | 26/09/2021 | Lamia | - | Panetolikos | 2:2 | ||||
| 5. Round | 03/10/2021 | Panetolikos | - | AEK Athen | 1:3 | ||||
| 22. Round | 05/02/2022 | Panetolikos | - | PAS Giannina | 0:1 | ||||
| 23. Round | 12/02/2022 | Apollon Smyrnis | - | Panetolikos | 0:0 | ||||
| 17. Round | 16/02/2022 | Panetolikos | - | Lamia | 1:0 | ||||
| 24. Round | 19/02/2022 | Panetolikos | - | Panathinaikos | 1:0 | ||||
| 25. Round | 26/02/2022 | Panetolikos | - | Volos NFC | 0:0 | ||||
| 26. Round | 06/03/2022 | Ionikos Nikea | - | Panetolikos | 1:2 |
Uruguay
Spain